Research Physiologist
Email:
phenry@usgs.gov
Office Phone:
301-497-5728
ORCID:
0000-0002-7601-5546
Location
12100 Beech Forest Road
Laurel
, MD
20708
US
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This study examined effects of the brominated flame retardant hexabromocyclododecane (HBCD) on the avian endocrine system. Japanese quail (Coturnix japonica) were exposed to multiple doses of HBCD over multiple generations through feed and by maternal deposition into the egg. Liver transcriptomes were examined to identify genes and pathways directly affected by HBCD to better understand the mechanisms of action in birds. RNA was extracted from liver of adults and embryos and analyzed (1x50 bp) on an Illumina HiSeq 2000. NCBI Biosample accessions and the raw counts that were input into the differential expression analysis are provided in this dataset. The raw sequence data are available at the NCBI Sequence Read...
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This work is part of a study of the immunological effects of exposure to alternative flame retardants in avian species. For the pathology portion of the study, spleens and bursas from American kestrels (Falco sparverius) exposed by egg injection to varying doses of short-chain chlorinated paraffins (SCCPs) and the flame retardant TBBPA-BDBPE were examined microscopically for architectural and cellular abnormalities. At euthanasia, spleen and bursa of Fabricius were collected and fixed in 10% neutral buffered formalin for histopathological assessment. Slides were processed and stained with hematoxalin and eosin as per standard procedure (Luna 1968). Quantitative and qualitative B and T cell parameters were assessed...
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- Observations of test subjects and hatching data - Body weight, organ/tissue weights - Biomarker data (oxidative stress indicators, oxidative DNA damage, thyroid hormones, histological findings) in various tissues - Chemical residues in tissues
Categories: Data;
Tags: American kestrel (Falco sparverius),
Birds,
Contamination and Pollution,
Ecotoxicology,
Ecotoxicology, All tags...
Environmental Contaminants,
Environmental Health,
Nonpoint-source Pollution,
Patuxent Wildlife Research Center,
USGS Science Data Catalog (SDC),
avian toxicity,
developmental toxicity,
emerging contaminants,
short-chain chlorinated paraffins, Fewer tags
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- Observations of test subjects and hatching data - Body weight, organ/tissue weights - Biomarker data (oxidative stress indicators, oxidative DNA damage, thyroid hormones, histological findings) in various tissues - Chemical residues in tissues
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Observations of test subjects and hatching data - Body weight, organ/tissue weights Biomarker data (oxidative stress indicators, oxidative DNA damage, thyroid hormones, histological findings) in various tissues Chemical residues in tissues
Categories: Data;
Tags: American kestrel (Falco sparverius),
Brominated flame retardants,
EHTBB,
Environmental Health,
Firemaster 550, All tags...
Maryland,
TBPH,
USGS Science Data Catalog (SDC),
avian toxicity,
developmental toxicity,
emerging contaminants, Fewer tags
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