Species populations are in a state of flux due to the cumulative and interacting impacts of climate change and human stressors across landscapes. Invasive spread, pathogen outbreaks, land-use activities, and especially climate disruption and its associated impacts—severe drought (see Figure 3 or the GPLCC), reduced stream flow, increased wildfire frequency, extended growing season, and extreme weather events—are increasing, and in some cases accelerating. These impacts are outpacing management and conservation responses intended to support trust species and their critical habitats. Our common goal is to craft successful adaptation strategies in the face of these multiple, interacting drivers of environmental change. New and enhanced decision support tools are needed that are standardized, transparent, and defensible for multiple partners. For this project, we enhanced decision support capability by (1) creating needed geospatial data products, (2) developing decision support tools, and (3) applying these products and tools to three focal species of interest in the Great Plains Landscape Conservation Cooperative (GPLCC)—all to support site-level management actions to maintain species populations and their habitats.