In this study, the calibrated Upper Rio Grande Basin PRMS model (Moeser and others, 2021) was run with projected climate data (Dixon and others, 2020) to produce a set of streamflow projections through the year 2099 that represent potential future changes in Rio Grande streamflow due to changes in climate. The PRMS model was forced with projections of daily precipitation, minimum daily temperature, and maximum daily temperature from 27 datasets for 1981- 2099. These datasets include data generated from three general circulation models (GCM; Table 1) included in the Coupled Model Intercomparison Project phase 5 (CMIP5) suite of models, using three statistical downscaling methods for three RCP scenarios. To arrive at potential climate-induced impacts, simulated streamflow for the model historical period (1981–2015) was subtracted from three simulated future time periods (2022-47,2048-73, 2074-99), and an analysis of changes in [naturalized] streamflow volume and timing was conducted for the Rio Grande and its tributaries.