Grasslands in the northern Great Plains are important ecosystems that support local economies, tribal communities, livestock grazing, diverse plant and animal communities, and large-scale migrations of big game ungulates, grassland birds, and waterfowl. Climate change and variability impact how people and animals live on and interact with grasslands, and can bring more frequent droughts, fires, or new plant species that make managing these landscapes challenging. Understanding how climate change and variability will impact grassland ecosystems and their management in the 21st century first requires a synthesis of what is known across all of these scales and a gap analysis to identify key areas to focus future research.