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Natural selection may result in local adaptation to different environmental conditions across the range of a species. Understanding local adaptation, in turn, informs management decisions such as translocation to restore locally-extinct populations. We used a landscape genomics approach to detect genetic signatures of selection related to climatic variation among desert bighorn sheep populations across their indigenous range in the western United States. This approach allowed us to investigate broad patterns of both neutral and adaptive genetic variation across very different environments. Analyses suggested that ancestry and isolation by distance were the most significant forces driving genetic variation in desert...