Understanding the cumulative impact of a suite of simultaneously occurring environmental stresses on stream water quality is essential for developing effective management and restoration strategies at the watershed scale. The conversion of naturally vegetated watersheds to urban or agricultural uses often results in degradation of stream water quality and such negative influences have been well documented. Nevertheless, the mechanisms through which land use and other physical factors (e.g., climate, topography, geology, hydrology) affect nutrient concentrations in streams ecosystems are still poorly understood. Here we present the results of an ongoing investigation of the effects of multiple stressors on the nutrient dynamics of 65 [...]