Abstract: Greenhouse gas-induced climate change will have notable effects on the Great Lakes region, in the atmosphere, land surfaces, and lakes themselves. Simulations of these effects were carried out using the Coupled Hydrosphere-Atmosphere Research Model (CHARM), driven by output from the Canadian General Circulation Model version 3 (CRCM3) for past and future time periods. This results in increased downward longwave radiation and near-surface air temperature. The air temperature increases during summer have strong spatial minima directly over the lakes that are limited to the lowest model layer and seem to be associated with frequent fog depicted by CHARM. Precipitation is also generally increased, with the most spatially coherent, [...]