The Yurok Tribe Environmental Program (YTEP) received a grant in 2012 from the North PacificLandscape Conservation Cooperative (NPLCC) with partial funding from the Northwest Climate Science Center (NWCSC) to conduct a study entitled, “Utilizing Yurok Traditional Ecological Knowledge to Inform Climate Change Priorities”. This final report summarizes the objectives, methods and results of final analysis of work performed during the project period (October 2012–March 2014). The report also includes information that may be relevant to other tribes and agencies interested in balancing the cultural and proprietary considerations regarding the collection and use of culturally sensitive Traditional Ecological Knowledge (TEK) and the goals of many tribes to utilize TEK in responding to the issues and needs arising from the impacts of climate change. Key findings have been incorporated into the final recommendations to the NPLCC regarding Yurok tribal science priorities for future research efforts related to the impacts of climate change on habitats, ecosystems and culturally important species of concern.