Abstract: The recognition of climate change issues facing tribal communities and indigenous peoples in the United States is growing, and understanding its impacts is rooted in indigenous ethical perspectives and systems of ecological knowledge. This foundation presents a context and guide for contemporary indigenous approaches to address climate change impacts that are comprehensive and holistic. Tribal communities and indigenous peoples across the United States are reenvisioning the role of science in the Anthropocene; working to strengthen government-to-government relationships in climate change initiatives; and leading climate change research, mitigation and adaptation plans through indigenous ingenuity. Unique adaptive capacities [...]