Researchers with U.S. Geological Survey Water Science Centers in Iowa, Kansas and Massachusetts collaborated to conduct a comprehensive literature search of both published and ongoing research (2000-present) that sheds light on the interactions between climate change, agriculture and water quality across the combined geographies of the Eastern Tallgrass Prairie and Big Rivers LCC and neighboring Upper Midwest and Great Lakes LCC. Project investigators compiled the information in a resource library by geographic location, providing an organized structure for future examination of all research related to interactions between climate change, agriculture and water quality in these two regions.