The Milk and St. Mary Rivers are international waterways straddling the United States and Canada and traversing four Tribal Nations before draining into the Missouri and South Saskatchewan Rivers respectively. Management of water resources in the region is challenged by the complexity of stakeholder interests, the limitations of existing management infrastructure, and by a limited characterization of the long-term streamflow and hydroclimatic variability across the area. We used existing records of natural streamflow to investigate the relationships between seasonal climate variability and differences in the timing and volume of flow from the headwaters to the prairie tributaries. Then, using a network of tree-ring chronologies to [...]