Healthy ecosystems benefit people, plants, domestic animals, and wildlife in Alabama. Diseases impact agriculture, public health and wildlife conservation. Focusing upon this subject, the Alabama Departments of Agriculture and Industries, Conservation and Natural Resources, and Public Health, together with Auburn University, will form a new coalition to develop a One Health framework to prepare and safeguard against current and emerging infectious disease threats. Our objectives center around enhanced surveillance, prevention, control, applied research, and training on wildlife health issues throughout the state.