The overarching objective is to understand how anthropogenic sources of inorganic contaminants (metals) affect the structure and function of aquatic ecosystems. Elements of the research include: 1) develop and apply analytical methods and models to understand and predict metal bioavailability and bioaccumulation in aquatic organisms; 2) define effects of metal exposure on aquatic species; 3) communicate research findings to scientific and regulatory communities to support the management of water resources.