Impacts of climate change on natural resources need to be evaluated in a range of geography and agricultural systems for better conservation planning. The objectives of this paper were to evaluate spatial sensitivity of predicted soil loss and runoff to climate change at large scales, and to simulate the “regional” impacts of climate change on soil erosion on the southern Great Plains. Relative climate changes at three spatial scales between 1950 to 99, and 2070 to 99, projected using HadCM3 under the A2a, B2a, and GGa1 emission scenarios, were used to generate changed climates for Chickasha, Oklahoma. The Water Erosion Prediction Project (WEPP) model was run for each climate scenario at three spatial scales with three tillage systems. [...]