Control of invasive sea lamprey recruitment from tributary streams is a major management objective in the Great Lakes, and benefits from barriers that prevent access to spawning habitat. As society moves toward removal of more tributary barriers due to concerns about native migratory fishes, aging infrastructure, and vulnerability to climate-driven flooding, it is important to assess the costs of alternative options for sea lamprey control. This project is integrating cost estimates for application of a lamprey-specific pesticide into cost-benefit optimization models used to support decisions about barrier removals that maximize restoration of habitat for native species. By integrating lamprey control options into our existing decision support tool, our team will aid decision makers in balancing the goals of efficient restoration of aquatic connectivity and effective management of harmful invasive species across thousands of tributaries in the Great Lakes basin.