A primarily stream-dwelling and obligate stream-breeding species, the foothill yellow-legged frog (FYLF) has declined from over half of its historical range, and a listing decision under the U.S. Endangered Species Act will likely be made in December 2021. Recent analyses suggest that the Southwestern California (SWC) clade is the most genetically unique and at the highest risk due to stressors in its geography, revealing the urgency of addressing the conservation of this clade. The rapid extirpation of some FYLF populations from the Central California Coast may have resulted from chytrid fungus. Therefore, strategic translocations from the remaining populations along the Central California Coast now could help reestablish additional [...]