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Filters: Contacts: {oldPartyId:17184} (X) > partyWithName: U.S. Geological Survey (X) > partyWithName: Barnett A Rattner (X)

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Reproductive Data for All Nests Monitored; Data for Mayfield Analysis; Eggshell thickness, nestling morphological measurements, nestling plasma stable isotopes, and nestling red blood cell oxidative DNA damage; Egg organochlorine pesticide, total PCB, flame retardants, and PCB toxic equivalent concentrations; Fish capture by osprey; Fish pools and size for contaminant analysis; Fish organochlorine pesticide, total PCB and flame retardants concentrations; Data for estimation of p,p’-DDE and total PCB biomagnification from fish to osprey eggs
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A seminal question in ecotoxicology is the extent to which contaminant exposure evokes prolonged effects on physiological function and fitness. A series of studies were undertaken with American kestrels ingesting environmentally realistic concentrations of the second-generation anticoagulant rodenticide (SGAR) brodifacoum (BROD). Kestrels fed BROD at 0.3, 1.0 or 3.0 µg/g diet wet wt for 7 d exhibited dose-dependent hemorrhage, histopathological lesions and coagulopathy (prolonged prothrombin and Russell’s viper venom times). Following termination of a 7 d exposure to 0.5 µg BROD/g diet, prolonged blood clotting time returned to baseline values within a week, but BROD residues in liver and kidney (terminal half-life...
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A heterologous thrombin clotting time assay (TCT) was used to measure the time for conversion of fibrinogen to fibrin using commercially available reagents. Human reference material included in the kit was diluted with imidazole buffered saline (IBS; 0.0125M imidazole-0.109 M sodium chloride, pH7.4) to generate a standard curve. Each kestrel plasma sample was thawed at 37ºC and diluted with IBS, and following incubation at 37ºC, the reaction was then initiated by the addition of bovine thrombin reagent supplied with the assay kit, with clotting time measured to 0.1 s. Fibrinogen concentration was determined in a single assay for each of the 3 study trials, with reference samples interspersed among study samples....
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Range finding trial in which kestrels were fed diets containing varying quantities of brodifacoum and signs of intoxication were monitored.
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The information provided in the Contaminant Exposure and Effects-Terrestrial Vertebrates (CEE-TV) Database profiles available geo-referenced information on contaminant exposure and effects in terrestrial vertebrates along the U. S. Atlantic, Gulf, and Pacific coasts (including Hawaii and Alaska) and the Great Lakes.
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Exposure of wildlife to Active Pharmaceutical Ingredients (APIs) is likely to occur but evidence of hazard and risk is limited. One exposure pathway that has received attention is trophic transfer of APIs in a water-fish-osprey food chain. Samples of water, fish plasma and osprey plasma were collected from Delaware River and Bay, and analyzed for 21 APIs. Only 2 of 21 analytes exceeded Method Detection Limits (MDL) in osprey plasma (acetaminophen and diclofenac) with plasma levels typically 2-3 orders of magnitude below human therapeutic concentrations (HTC). We built upon a screening level model used to predict osprey exposure to APIs in Chesapeake Bay and evaluated whether exposure levels could have been predicted...
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- Observations and treatment of various species of raptorial birds admitted to a rehabilitation facility, and of nestling barn owls observed and sampled in the field - Clotting time parameters (prothrombin time, Russell’s viper venom time, fibrinogen concentration) - Anticoagulant rodenticide residue data
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In the fall of 2005, dead and dying great blue herons (Ardea herodias) exhibiting emaciation, lethargy, inability to fly and a hard abdomen (steatitis confirmed at necropsy) were observed at Poplar Island and nearby Coaches Island (Rattner et al. 2006). Birds were hand captured at or near impoundments (cells) and ponds that contained large algal blooms, and because of poor prognosis were euthanized. Seemingly healthy great blue herons were subsequently collected at Blackwater National Wildlife Refuge. Blood and fecal samples were collected, and submitted to Antech Diagnostics (Lake Success, New York) for Avian/Exotic Combined Blood Count, Comprehensive Avian Chemistries, Fecal Cultures and Vitamin E analysis. Liver...
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Trial examining blood clotting function response in kestrels initially fed a diet containing chlorophacinone (CPN) or brodifacoum (BROD), and following a recovery period, kestrels were challenged with a diet containing chlorophacinone. Kestrels received two 25 ± 0.1 g NBP meatballs daily for a 7-day period containing either vehicle, 1.5 µg CPN/g wet wt diet (i.e., 1.5 ppm chlorophacinone) or 0.5 µg brodifacoum/g wet wt (i.e., 0.5 ppm brodifacoum) during an initial exposure phase. Following 7 day recovery period, these kestrels were then fed 0.75 µg CPN/g wet wt diet (i.e., 0.75 ppm chlorophacinone) for a 7 day challenge exposure phase. Hereafter, these groups are designated control-chlorophacinone challenge (CON-CPN),...
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Citrated plasma samples were sent to the University of Miami Avian and Wildlife Laboratory for clinical determination of total protein, plasma electrophoresis (pre-albumin, albumin, alpha 1 globulins, alpha 2 globulins, beta globulins, gamma globulins) and aspartate aminotransferase and creatine phosphokinase activities.
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Trial in which coagulopathy and the time course of recovery of clotting function was determined in kestrels fed a diet containing brodifacoum.
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-Test subject identification information (sample collection site and date, test subject identification number, and sample number) -Clotting time parameters and comments (prothrombin time, Russell’s viper venom time, fibrinogen concentration, and coefficient of variation for replicate analyses)
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- Observations of test subjects, - Body weight, organ/tissue weights - Biomarker data (oxidative DNA damage, thyroid hormones, corticosterone, gene expression) in various tissues - Residues as percent of administered dose - Tissues to plasma rations - Metabolites and ratios - Elimination half-lives
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- Observations of test subjects, - Body weight Reproductive Data for All Nests Monitored - Estimates of test diet consumption - Hematocrit - Clotting time parameters (prothrombin time, Russell’s viper venom time, fibrinogen concentration)
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An important component of assessing the hazards of anticoagulant rodenticides to non-target wildlife are observations in exposed free-ranging individuals. The objective of this study was to determine if environmentally realistic, sublethal first-generation anticoagulant rodenticide exposures via prey, can result in direct or indirect adverse effects to free-flying raptors. We offered black-tailed prairie dogs (Cynomys ludovicianus) that had fed on Rozol® Prairie Dog Bait (0.005% active ingredient chlorophacinone) to six wild-caught red-tailed hawks (RTHA, Buteo jamaicensis), and uncontaminated black-tailed prairie dogs to two wild-caught RTHAs for 7 days. On day 6, blood was collected from all eight RTHAs to determine...
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Body weight and weight change during course of study, estimates of food and brodifacoum consumption, observations of test birds during feeding trial and at necropsy, hematocrit, and prothrombin time
    map background search result map search result map Investigation of pharmaceuticals in water, fish, and ospreys nesting in Delaware River and Bay Examination of contaminant exposure and reproduction of ospreys (Pandion haliaetus) nesting in Delaware Bay and River in 2015 Is Sensitivity to Anticoagulant Rodenticides Affected by Repeated Exposure in Hawks? Use of blood clotting assays to assess anticoagulant rodenticide exposure and effects in free-ranging birds of prey Toxicokinetics of imidacloprid-coated wheat seeds in Japanese quail (Coturnix japonica) and evaluation of hazard Brodifacoum toxicity in American kestrels (Falco sparverius) with evidence of increased hazard upon subsequent anticoagulant rodenticide exposure 1. Results of Trial 1 2. Results of trial 2 3. Results of trial 3 4. Results of Blood Clotting Assays 5. Results of Trial 3 Blood Chemistry Analysis Assessing Exposure, Physiological Effects, and Geographic Scope of Anticoagulant Rodenticides in the Critically Endangered California Condor Toxicological responses to sublethal anticoagulant rodenticide exposure in free-flying red-tailed hawks Great Blue Heron collection at Poplar Island Complex and Chesapeake Marshlands National Wildlife Refuge Complex The Contaminant Exposure and Effects-Terrestrial Vertebrates database (CEE-TV) Brodifacoum isomer formulation study Toxicokinetics of imidacloprid-coated wheat seeds in Japanese quail (Coturnix japonica) and evaluation of hazard Brodifacoum toxicity in American kestrels (Falco sparverius) with evidence of increased hazard upon subsequent anticoagulant rodenticide exposure 1. Results of Trial 1 2. Results of trial 2 3. Results of trial 3 4. Results of Blood Clotting Assays 5. Results of Trial 3 Blood Chemistry Analysis Is Sensitivity to Anticoagulant Rodenticides Affected by Repeated Exposure in Hawks? Brodifacoum isomer formulation study Assessing Exposure, Physiological Effects, and Geographic Scope of Anticoagulant Rodenticides in the Critically Endangered California Condor Great Blue Heron collection at Poplar Island Complex and Chesapeake Marshlands National Wildlife Refuge Complex Investigation of pharmaceuticals in water, fish, and ospreys nesting in Delaware River and Bay Examination of contaminant exposure and reproduction of ospreys (Pandion haliaetus) nesting in Delaware Bay and River in 2015 Toxicological responses to sublethal anticoagulant rodenticide exposure in free-flying red-tailed hawks Use of blood clotting assays to assess anticoagulant rodenticide exposure and effects in free-ranging birds of prey The Contaminant Exposure and Effects-Terrestrial Vertebrates database (CEE-TV)