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  4. Viral loads, histology, and adverse events in transgenic mice after passive transfer of serum from black-footed ferrets (Mustela nigripes) used to assess the anti-viral efficacy of a subunit SARS-CoV-2 vaccine candidate

Viral loads, histology, and adverse events in transgenic mice after passive transfer of serum from black-footed ferrets (Mustela nigripes) used to assess the anti-viral efficacy of a subunit SARS-CoV-2 vaccine candidate

Dates

Publication Date
Start Date
2021-03-22
End Date
2022-03-30

Citation

Leon, A.E., Garelle D., Hartwig, A., Falendysz, E.A., Ip, H.S., Lankton, J.S., Tretten, T.N., Spraker, T., Bowen, R., and Rocke, T.E., 2022, Viral loads, histology, and adverse events in transgenic mice after passive transfer of serum from black-footed ferrets (Mustela nigripes) used to assess the anti-viral efficacy of a subunit SARS-CoV-2 vaccine candidate: U.S. Geological Survey data release, https://doi.org/10.5066/P9GZEXN9.

Summary

This data set provides biological information from of a captive study of transgenic mice that received either passive serum transfers from black-footed ferrets (BFFs) that were vaccinated against SARS-CoV-2 or BFFs that were unvaccinated, or a monoclonal antibody against SARS-CoV-2 or lastly a placebo. After these treatments mice were challenged with SARS-CoV-2. The data included here have viral loads in the lungs of treated mice, as well as histological results from various tissues collected at the end of the study.

Contacts

Point of Contact :
Ariel E Leon
Originator :
Ariel E Leon, Della Garelle, Airn Hartwig, Elizabeth A Falendysz, Hon S Ip, Julia S Lankton, Tyler N. Tretten, Terry Spraker, Richard Bowen, Tonie E Rocke
Metadata Contact :
Ariel E Leon
Publisher :
U.S. Geological Survey
Distributor :
U.S. Geological Survey - ScienceBase
SDC Data Owner :
National Wildlife Health Center
USGS Mission Area :
Ecosystems

Attached Files

Click on title to download individual files attached to this item.

Leon2022_metadata.xml
Original FGDC Metadata
View 		40.88 KB application/fgdc+xml
Transgenic mouse BFF serum_adverse events.csv 4.25 KB text/csv
Transgenic mouse BFF serum_histo 1.csv 1.53 KB text/csv
Transgenic mouse BFF serum_histo 2.csv 1.37 KB text/csv
Transgenic mouse BFF serum_viral loads.csv 3.11 KB text/csv

Purpose

The data were collected to determine the in vivo serum anti-viral activity of BFFs vaccinated against SARS-CoV-2, as compared with that of unvaccinated BFFs, as well as that of monoclonal antibody treatment against SARS-CoV-2.

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  • National Wildlife Health Center
  • USGS Data Release Products

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Identifiers

Type Scheme Key
DOI https://www.sciencebase.gov/vocab/category/item/identifier doi:10.5066/P9GZEXN9

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